ameliorating effect of zingiber officinale (ginger) hydroethanolic extract on scopolamine-induced memory impairment in adult male rats
نویسندگان
چکیده
background and aims: the spice zingiber officinale or ginger possesses antioxidant and neuroprotective effects. in this study we hypothesized that treatment with hydroethanolic extract of ginger (50, 100 and 200 mg/kg, p.o) would have an effect on the scopolamine-induced memory impairment in rats.methods: in this experimental study, 64 male wistar rats were divided into eight groups (8 rats in each group): normal saline, scopolamine (1 mg/kg), ginger extract (50, 100 and 200 mg/kg), or scopolamine (1 mg/kg) plus ginger extract (50, 100 and 200 mg/kg). memory impairment was induced with a single injection of scopolamine (1 mg/kg, i.p). cognitive functions were evaluated using passive avoidance learning (pal) task. retention test was carried out 24 hours after training, and the latency of entering the dark compartment [step-through latency (stl)] and the total time in the dark compartment (tdc) were recorded. all statistical analysis was carried out at 5% level of significance using spss version 21. the data were analyzed by anova followed by tukey’s test.results: the time latency in scopolamine-treated group was lower than control (p
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effect of zingiber officinale (ginger rhizomes) hydroethanolic extract on hyoscine-induced memory impairment in adult male rats
background: the spice zingiber officinale or ginger possesses antioxidant activity and neuroprotective effects. in this study we hypothesized that treatment with hydroethanolic extract of ginger (50, 100 and 200 mg/kg, p.o) would effect on the hyoscine-induced memory impairment in rats. methods: in this experimental study 64 male wistar rats were divided into eight groups (8 rats in each group)...
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عنوان ژورنال:
advanced herbal medicineناشر: shahrekord university of medical sciences
ISSN
دوره 1
شماره 4 2015
کلمات کلیدی
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